02- CLINICAL DEVELOPMENT

Women’s Health

Now there’s a money spinner! <<<Health>>>

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Spinal Tap To Diagnose Alzheimers Risk

I’m not surprised they’re reticent! Look up Collins paper in Nature a few weeks ago – brilliant stats assessment of IP-Mass Spec to measure amyloid in PET scans and CSF samples And it’s a very accuratealternative to CSF sampling I do wonder if it’s commercially viable thought (I don’t know enough about IP-MS) <<<AD Risk […]

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Diet And Alzheimers

Thank god for Statisticians – I hate it when clinicians refer to single cases At least there is a big follow up survey And this isn’t rocket science either! <<<DIET>>>

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Apple Move Into eMHR

Now this is fascinating – Apple trying to match medical records with subjects on smartphones Would this mean we could do the ultimate in virtual trials Recruit patients from iPhone database, import history data, order and provide medication electronically, prompt patients to take meds and to record ePRO data and even record automically vital signs. […]

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More Bad News In Alzheimer’s

This time it’s Takeda’s turn with pioglitazone (repurposing diabetic treatment) in Phase III <<<AD Failure>>>

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Anti-Depression Meta Analysis

Just shows you the value of ‘weight of evidence’ ie numbers of subjects >>>Depression Meta Analysis<<<  

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Pill To Improve Fitness?

Obviously these guys aren’t sportsmen! Just showing you can extend endurance doesn’t improve fitness We had a soluble glucuronic acid did the same thing Preferentially burning fat may be useful treatment in obesity <<<LINK>>>

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MHRA To Develop FDA Links

Apparently the MHRA is may consider developing links with the FDA post Brexit now the the EMA will move out of London The aim would be to have agreement in place to allow fast track approvals. Now that would be interesting >>>   http://www.thetimes.co.uk/edition/business/britain-eyes-american-drug-approval-pact-0mwrj7g6f

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Red Bull As Symptomatic Treatment In AD?

Keith’s CogTrack finds some interesting effects on short/long term memory and speed of retrieval >>> Study: Red Bull energy drink boosts memory performance

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Yet Another Failure In AD

This time Merck’s BACE inhibitor of amyloid beta >> http://www.pharmatimes.com/news/merck_pulls_plug_on_late-stage_alzheimers_trial_1186737?utm_source=PT+Daily+Newsletter&utm_medium=email&utm_campaign=pt+daily+news+alert

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