OUR BLOG

Butterfly IQ – Ultrasound on the smartphone

Now this is what I call a useful app 🙂 <<<Ultrasound>>>

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Medidata AI Platform To Make Placebo Groups Redundant!

Never did like Medidata products but this one will have Bradford Hill turning in his grave! <<<TheTIMES>>>    

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Merck Couldn’t Afford Axon’s Vaccine Then?

Another antibody targeting Tau protein for the treatment of AD! <<LINK>>

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Pill To Improve Fitness?

Obviously these guys aren’t sportsmen! Just showing you can extend endurance doesn’t improve fitness We had a soluble glucuronic acid did the same thing Preferentially burning fat may be useful treatment in obesity <<<LINK>>>

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Another Failure In AD: Neurotrope

Bryostatin’s mechanism of action is to modulate protein kinase activity  (pka) and reduces amyloid and tau apparently Still doesn’t work >>> LINK<<<

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Smartphone App To Automatically Produce Insulin

If this isn’t the most amazing use of a Smartphone I don’t know what is!!! >>>LINK<<<

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Brain Age Predictor Of Longevity?

I really don’t get this! What about all the other confounding factors??? >>> LINK <<<

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Smartwatch For Clinical Trials At Last!

Now this is what I call a ‘usable’ device for collecting lifestyle data away from the clinic. No interfering from the patient! <<<LINK>>

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Continuous Glucose Monitoring

Now that is interesting >>> <<LINK>>>

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Mobile Data Analysis!

I really like the MC10 Biostamp Looks like all the mobile data (from motion sensors) here is being used in our gaydar plots 🙂 >>>LINK<<<

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Is It Worth Meeting The FDA Pre-IND?

If there’s anything novel about your programme? Then it’s a no brainer !!! >>> <<LINK>>>

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About Time!

It’s about time the government (NICE) tightened up on Pharma pricing of drugs! >>LINK<<

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Merck To Work With Amazon (AWS) To Use Alexa In Chronic Disease

Really! Pharma intends to get voice enabled computers to remind patients about nutrition plans and dosing at least initially in Type II diabetes >>> <<LINK>>

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Just Where Do All The Stupid Drug Names Come From?

Some woman – Octavia Spencer’s family member names 🙂 And apparently they’re associated like Rorshach Splotches! <<LINK>>  

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Vitrification Or Organ Freezing

Freezing organs for donors is fine The problem comes when trying to reheat them for use! Using silica-coated iron oxide nanoparticles as part of the freezing process is a very neat way of solving the warming problem and helping organs to last longer in the deep freeze >>> <<LINK>> 

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Wearables In Clinical Trials!

Takeda using the iWatch to collect ‘real life’ data from Parkinson’s patients Including continuous vitals monitoring with prompted cognition and mood data in ePRO form >>> http://www.fiercepharma.com/marketing/takeda-partners-cognition-kit-wearable-study-for-depression?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiWXpka05qVTBaRGxrWm1abCIsInQiOiJpSmVueXM1RDBYRHRGVklGeVBscThBYzRFVG1uZGgrT2F3UXBycjR3ZmFKSHJLeVA5QWJGbFo0WUFNQzZyenJKVzJhZ3lOdXIwK1ppXC9yNnZJYXV2MDkrenJqM0g0d1E2blBvS0ZDeTlXUkc3ZjJDS2gwd3k2RVRCcmczMFFMRXMifQ%3D%3D

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Personalised Adverse Events!

Another use for stem cell technology I did talk to Aidan Courtney at Censobio.com who expects to do a similar thing – predicting response to AD treatment with stem cell testing>>> http://newatlas.com/stem-cells-personalized-testing-cancer-drug/48178/?utm_source=Gizmag+Subscribers&utm_campaign=08c7982cf2-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-08c7982cf2-91677545

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AD Another Phase III Trial- Roche/Genentech

AC Immune’s crenezumab already has one Phase III trial in progress now they’ve started another. All based on their ‘failed’ Phase II study. Where’s the sense – or is it just me >> http://www.fiercebiotech.com/r-d/roche-starts-second-alzheimer-s-phase-3-anti-abeta-drug?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTkdJMFpUZzFaakkwTmpBeCIsInQiOiJoVWxqQ2tsbFVjSjlWSThTK3pZM2lHTFY0TTI3NGVSamFqUjRINnVCdzlZdkM0S0RwODBzU0hleTZmckg4QjcyaEFwSVhSOHd3XC9xUnZ5TWNGTzZweWordllsZU9EZ2pOVWVSSHRLNnJqTWpEekl4eWkweHpEejN2Y2xEcTlVYzIifQ%3D%3D

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AD Another Phase III Failure – Accera

Did they really think this was going to work in the first place A triglyceride and a re-formulation with less bioavailability post Phase II Who funds these ideas! >> More Phase 3 disappointment in Alzheimer’s disease  

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MHRA To Develop FDA Links

Apparently the MHRA is may consider developing links with the FDA post Brexit now the the EMA will move out of London The aim would be to have agreement in place to allow fast track approvals. Now that would be interesting >>>   http://www.thetimes.co.uk/edition/business/britain-eyes-american-drug-approval-pact-0mwrj7g6f

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Microsoft Getting Into Healthcare?

Looks like they want to use NExT to interrogate medical records in a big way>>>> Microsoft refocuses in healthcare, teams with UPMC on innovation

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Taking Mobile Tech One Step Too Far?

How about Transhumanism for the ultimate connection to technology >> http://newatlas.com/transhumanism-mainstream-era-popular/47941/?utm_source=Gizmag+Subscribers&utm_campaign=451d4e2031-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-451d4e2031-91677545

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Red Bull As Symptomatic Treatment In AD?

Keith’s CogTrack finds some interesting effects on short/long term memory and speed of retrieval >>> Study: Red Bull energy drink boosts memory performance

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Yet Another Failure In AD

This time Merck’s BACE inhibitor of amyloid beta >> http://www.pharmatimes.com/news/merck_pulls_plug_on_late-stage_alzheimers_trial_1186737?utm_source=PT+Daily+Newsletter&utm_medium=email&utm_campaign=pt+daily+news+alert

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Another Phase III Trial In AD Going ‘Gungho’!

Apparently 11 patients treated is sufficient now for developers to go straight into a big Phase III trials Sounds like Lilly all over again! Whatever happened to classic drug development? Obviously the review article I did with Bengt Winblad and Julian Gray didn’t put any one off >> http://www.fiercebiotech.com/biotech/early-win-means-phase-3-test-way-for-axovant-s-dementia-drug?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTTJRNE1UQTNNV1prWVdRMCIsInQiOiI3UlpZdEFXMTRldkIySSt3WFQyaitKVGl2YkNENWRNY0V1eUtESjJ5ellmQVVmaURvWXNIbmppYmxjSmZUczA3TkwxejRZMnpvSmlXdTExZk1aYUFIWG1JM1RTT0d4ZGpaR0dGckVybVdMQTgrWDc0VFdBN0ZcLzdrcllkSlh3UjgifQ%3D%3D

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Financial Analysts Try to Be Statisticians in NASH Trial!!!

Very interesting new press release No idea why the Intercept share price went down given that it’ll be much easier now to get a positive trial result with statistical significance on only one or other of the co-primary endpoints and it’s reduced the number of subjects required in total as well! It certainly does raise […]

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Lab On A Chip Future

Fascinating stuff from Stanford using electrophoresis in a microfluidic chamber to diagnose diseases And affordable >>> http://newatlas.com/stanford-microfluidic-lab-on-a-chip/47775/?utm_source=Gizmag+Subscribers&utm_campaign=a8bafb40ef-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-a8bafb40ef-91677545

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Yet Another Failure In AD!!!

Lundbeck’s 5-HT6 antafonist (idalopirdine ) has failed in 3 attempts >>> http://www.fiercebiotech.com/biotech/lundbeck-calls-time-alzheimer-s-drug-after-more-failure?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTkdNNU1UZGxNR05pTjJJeiIsInQiOiJxWnhDQTcySXZCQm1MeTE4THZXWEVnTlZGa1JNMVRVOVNmVFFCUHZTWjJrZkRBdjJPY2Zxd0l0aVdOOEZaMVwvWFdSNUI0dlNaaFArWWd2eVNNUGJndllOVDZKdjZ2ZUREdmQyWDIzcTdmOFRtMHpuYmp1QUpSYUxObU9mSmo2NXQifQ%3D%3D

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Is This The Holy Grail?

Bioelectric systems Sensing the environment and triggering response through electrochemical response Disease/Illness detection and treatment ‘all in one’!!! >>>> http://newatlas.com/cyborg-technology-scientists-create-bioelectric-hybrid-cells/47481/?utm_source=Gizmag+Subscribers&utm_campaign=69a7338016-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-69a7338016-91677545

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War On AD?

News items in the Times over the last 2 days. Seems like the disease is still winning for all our efforts >>> http://www.thetimes.co.uk/past-six-days/2017-01-30/news/drug-failure-deals-blow-to-dementia-sufferers-ll27jd65r http://www.thetimes.co.uk/edition/news/century-long-war-on-alzheimers-edges-towards-uncertain-endgame-n9mm9k0jk

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Does This Mean There’ll Be Competition For LSD In Dementia In Future?

The benefits of microdosing LSD, although cognition wasn’t specifically mentioned>>>> http://newatlas.com/lsd-long-trip/47551/?utm_source=Gizmag+Subscribers&utm_campaign=2a58092796-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-2a58092796-91677545

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More Clinical Trials In AD News

Another Phase II with an Anit-Tau antibody (AbbVie) Does this bode well for the ‘front runner’ Axon especially after TauRx fell at the first? And what about the others in the pack at the back: Eisai/Biogen, Bristol-Myers Squibb and Astellas? >>>> eyJpIjoiWWprNU56UmhPR1ppT1RFeCIsInQiOiJxTTlsOWcxaWZkU3YwVmF2TFFYOUhNTVg1eDJpTVVPWGRVUGN4cXdFSjlLMzcyM2J6Tld0OWc2OEpjekE2MGdBeVJORmFWelZ5Sk5yNkdadSs1VkhKajMwYjRBSGthdHlFbHVFRGh6UWo5aHdyNjJLclY1NnpPb0RlQ25GWjdVRCJ9  

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Challenges To Conducting Clinical Trials

Not a formal survey but this poll shows what concerns there are for clinical trials Complexity / Regulations / Costs / Patient access / Staff? / Technology / Oversight / New drugs Bring it on! 🙂 >>> http://www.clinicaltrialpartnershipsblog.com/2016/11/report-8-biggest-challenges-facing.html?utm_source=PCT+Blog+Registrations&utm_campaign=8ce0a92a2a-PCT_Content12_bloglist_top5_04_01_17&utm_medium=email&utm_term=0_81d996f2c9-8ce0a92a2a-132135521&goal=0_81d996f2c9-8ce0a92a2a-132135521

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The Internet of ‘Medical’ Things

‘Digital health’ tools to support clinical trial conduct – including management and monitoring Link it all together with ‘mHealth’ – patient retention/questionnaires through apps and sensors in wearable tech- to get the ultimate clinical trial? >>> http://www.clinicaltrialpartnershipsblog.com/2016/09/clinical-trials-and-iot-how-mhealth.html?utm_source=PCT+Blog+Registrations&utm_campaign=8ce0a92a2a-PCT_Content12_bloglist_top5_04_01_17&utm_medium=email&utm_term=0_81d996f2c9-8ce0a92a2a-132135521&goal=0_81d996f2c9-8ce0a92a2a-132135521

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The Future For Clinical Trials?

Interesting thoughts from Exco (some good some not so good)!!! -Break with tradition and adopt new technology -Make patients the centre of the trial -Collect data seamlessly (no human involvement and therefore validation issues) -Use patients own devices I just hope they don’t forget the primary objective of any trial is to assess the efficacy […]

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Ethical Pharma?

And you wonder why pharma have a bad name Some of these companies you might expect but not Pfizer They were very sneaky selling to Flynn and getting them to increase the price of phenytoin for epilepsy by 2600% ! I bet the £84m fine didn’t hurt too much! >>>> http://www.thetimes.co.uk/article/duplicate-permits-let-manufacturers-keep-their-dominance-fsrkp3lnq?shareToken=fdb66b66afe630645809670d8992a145  

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Another Reason Why I Hate Facebook!

Humans are a lazy species anyway – this should make us worse!!! >>> http://www.thetimes.co.uk/article/facebook-boss-wants-service-with-ai-smile-dst9g3gzw?shareToken=3c96790ec26b35178b4e275351639357

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NICE To Work With FDA On MedTech!

More close relations to help developers of diagnostic tests and medical devices apparently! >>> http://www.pharmatimes.com/news/nice_links_with_fda_to_accelerate_access_to_med_tech_1182083

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Another New Treatment For AD?

But this one is novel – wearable tech Flickering light stimulation! >>>> Non-invasive visual stimulation to treat Alzheimer’s disease

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New Treatment For AD?

M1 muscarinic receptor proteins for the improvement for cognition have been used before. One without serious side effects would be interesting 🙂 >>>>  

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Graphene Can Detect Cancerous Cells!!!

Apparently graphene molecules are very sensitive and cancer cells modify charge at its surface. The change in atomic vibration is then detected. Wow whatever next for graphene! >>> http://newatlas.com/graphene-cancer-detection/47044/?utm_source=Gizmag+Subscribers&utm_campaign=69b4aefc4e-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-69b4aefc4e-91677545

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Botox for Depression!

As an injection as well! >>> http://www.fiercepharma.com/marketing/allergan-eyes-depression-as-blockbuster-botox-next-big-stage?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTVRKbU0yVmlOakV6WlRNMyIsInQiOiI1UytxY3FlVmd6cWcwSldsbHptMTFHUFV3R1hlQTd3ZVBtNExXY2dSYWF2SnhCb0dOUlk2NGJtSlA4MENXMFg2eCtITm40Qzd4WGltK3c0Y2FPR2tjYmdvb3FDdmVpZWNRNDZTSXRSQlRxQTBseDZCVHczUmlHUlwvbkQrcVFQK3QifQ%3D%3D

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Chitosan ‘Meat Glue’ For Wound Healing

Amazing stuff – transglutaminase – a natural protein-binding enzyme Bioplastic from crustacean shells bonds anything from wounds to implanted devices From Harvard Wyss >>> http://newatlas.com/meat-glue-crustacean-shells/46717/

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Novel Administration Of SubCut Drugs

Would love to link control of drug administration from patch via smartphone app measuring blood concentration at same time 🙂 From KTH Stockholm >>> http://newatlas.com/two-tone-microneedle-patch/46901/?utm_source=Gizmag+Subscribers&utm_campaign=49f8e00b77-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-49f8e00b77-91677545

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Here We Go Again!

Lilly are off again only one day after the announcement of the failure of solanezumab at CTAD When will they learn protein plaques is not the answer!!! >>> http://www.fiercebiotech.com/biotech/after-ph3-failures-lilly-signs-new-alzheimer-s-drug-pact-astrazeneca

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App For Repeat Prescribing Meds

Very simple idea to solve a huge practical problem of prescribing NHS meds. Adding technology then extends its potential – to providing reminders for taking meds and even info on the product use and side effects >>>> http://www.thetimes.co.uk/article/the-new-way-to-help-the-medicine-go-down-c78rdvzmr   https://www.echo.co.uk/

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Microbiome And CNS Diseases

Not so strange  anymore. Other already working on gut bacteria to treat IBS so why not>>>> http://www.genengnews.com/gen-news-highlights/parkinson-s-disease-and-gut-microbiome-linked/81253492

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Bikes For $1bn !!!!

Interesting idea if it works low molecular weight versions of peptides that can target varying types of tumours (Respiratory/CVS/Metabolic) with the benefit of ‘tuning’ of PK  profiles >>>> http://www.pharmatimes.com/news/az,_bicycle_pair_up_to_develop_bicyclic_peptides_1179714?utm_source=PT+Daily+Newsletter&utm_medium=email&utm_campaign=pt+daily+news+alert

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Recent Big Failure For Biotech

Arrowheads failure in Hep B with ARC-520 in primates is a reminder that although there is loads of promise for new developments  – Not everything works! >>>> http://www.fiercebiotech.com/biotech/arrowhead-snaps-after-trial-hold-as-it-targets-major-layoffs-ditches-programs?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTURReE9XRXdOREEwWlRkaSIsInQiOiJqdGYwTStIVVc2ZCtYZGhHZm82VzREMGhqb0R5SmxTeFFzK2hrNGN0czdnTUk2b2NFaWtFajI0XC9TWlVETVwvSEZZazhjMnlLODIrTnpuV3hmZTU0VmZ4SjdUQTdwY2ZXMHdDRkh5UENwYzNZPSJ9

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Slowing The Ageing Process!

Metformin (old drug for diabetes) apparently has potential for slowing the ageing process. It can’t just be that it decreases hepatic production of glucose. As far as I can work out metformin (through biguanide–protein interactions ) may have ‘key role’ on microbiota which in turn influence and regulate age-associated morbidities.!!! Ahhh this might be key – plus […]

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Nothing Works In Stroke (Except TPA) ?

Interesting news on rodents from University of Manchester An approved RA drug (interleukin-1 receptor antagonist (IL-1Ra) may be able to treat Stroke patients as early research shows it limits cell death and potentially promotes new neurons >>> http://www.sciencedirect.com/science/article/pii/S0889159116305153

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Monitoring Drug In Skin Patches!!!

Onusblue from Derma-Tec The patch changes colour based on the level of drug detected They’re using this for alcohol at the moment but the possibilities are massive>>> http://newatlas.com/onusblue-color-gradient-alcohol-drug-detection-patch/46584/?utm_source=Gizmag+Subscribers&utm_campaign=5d70b80327-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-5d70b80327-91677545

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Artificial Muscles

Wow – muscles from nylon and conductive ink!! >>> http://newatlas.com/mit-robot-muscles-nylon/46611/?utm_source=Gizmag+Subscribers&utm_campaign=5d70b80327-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-5d70b80327-91677545  

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Lilly Spends >$150m And Share Price Down 14%

Solanezumab ‘fails’ in Alzheimer’s at last Hate to say ‘we told you so’ all along! Julian, Bengt and I said so in our review article last year. There’s no substitute for the good old fashioned ordered process of clinical development – Learn first (Phase II) then Confirm (Phase III) Biogen (aducanumab) next? >>>> http://www.fiercebiotech.com/biotech/alzheimer-s-hopes-dashed-as-lilly-gives-up-amyloid-drug-solanezumab?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiWVdNMVltTXlPR1kyWlRjdyIsInQiOiI1NGFBR2dHK1BNXC9GRmkxdVVcL3I5K2I3dEtiVWkwbXppbTdPdmhpQkJlRFwvK1dvK0lmYmt4a25WZVRhbWJQd1NQQ3ZibkZJWlwvUzJzZ1Njck9hXC9qVGd3M0ptZFZmVVduZVBNRnFyVHhIR0xJPSJ9

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A Hot Topic: Reducing Screen Failures In AD

My mate Tom’s approach to reducing screen failures in AD A complex statistical adaptive technique – REALLY! >> http://www.clinicalleader.com/doc/improving-screen-failure-and-recruitment-rates-in-alzheimer-s-disease-clinical-trials-0001?vm_tId=1965472&user=c4f6390a-527b-4ba6-97c0-6eff283b345d&utm_source=et_6212879&utm_medium=email&utm_campaign=CLNCL_11-21-2016&utm_term=c4f6390a-527b-4ba6-97c0-6eff283b345d&utm_content=Improving+Screen+Failure+And+Recruitment+Rates+In+Alzheimer%27s+Disease+Clinical+Trials  

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Ergomed CRO Discounts Costs Of Development

The Ergomed CRO services provider model seems to involve discounting the clinical management costs for shares in the development rights of the new compound Sounds like bit of an extreme and risky way of getting business to me >>> http://www.proactiveinvestors.co.uk/companies/news/124711/ergomed-s-hybrid-strategy-gives-it-plenty-of-ammo-124711.html

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Plethora Markets Fortacin For PE

We worked on the Phase II premature ejaculation programme in 2007 What have they been doing for nearly 10 years! >>> http://www.pharmatimes.com/news/uk_launch_for_premature_ejaculation_spray_1176726?utm_source=PT+Daily+Newsletter&utm_medium=email&utm_campaign=pt+daily+news+alert

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Mobile Health Tech Favourites

Just a few of mine (especially the patch) >>> https://www.mc10inc.com/our-products/biostamprc http://www.clouddx.com/index.html http://newatlas.com/aezon-aegle-arc-diagnostic-tricorder-xprize-health/33806/   The Aezon lot are just students and they don’t even have a Website 🙂 AND If you want to collect ePRO data as well >>> Axon    

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Typical Allergan!!!

One way to make more sales Provide the diagnostic test to find new patients >>> http://www.fiercepharma.com/marketing/allergan-teams-up-ibs-d-platform-to-identify-potential-new-viberzi-patients?mkt_tok=eyJpIjoiTURJNU5tWmxOVGMxTWpjeiIsInQiOiJXN3VaVFhrdHdwWEFsTzkxRDg5MWJXSG5RTmJmY0E3YnJwSloyQU9zZjZkU2N3MFg3QndzYmdHZnRVSUxGYzZma1FZZjNCZ0p1QzhmUGhORnJSdXdqZmhCdStDOGhEMU5yd1BlbTU5QStaST0ifQ%3D%3D&mrkid=938224&utm_medium=nl&utm_source=internal

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Animated Characters In Pharma Marketing!!!

Hilarious! Scroll down to the bottom of the article (don’t read it) They just click on some of the characters they’ve dream’t up! Which do you reckon is the best/worst? >>> http://www.fiercepharma.com/special-report/top-10-animated-characters-pharma-marketing   >>> The Mucinex Snot Monster is my favourite!!!

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Great Use For Wearable Tech In IBD

Great way to get ‘real time’ and probably more reliable ‘primary’ data in a problem condition without resorting to messy diary cards Excellent for motivating patients as well! >>> http://www.fiercepharma.com/marketing/takeda-looks-for-entyvio-boost-ibd-wearable-tech-program

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Binge Eating Disorder (Shire)

Trust my old company to come up with this one 🙂 >>>> https://www.shire.com/en/newsroom/2016/october/yjizb2 I didn’t even know BED was an illness!

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New ‘Validated’ Fitness Tracker!

See>>> http://www.cloudtag.com/ And it’s been ‘validated’!!! >>> http://www.cloudtag.com/2015/10/26/accuracy-results-from-user-testing/ Sorry – correlation is just not the way to validate 2 methods! They should specify an acceptable margin for the paired differences (2 measures are never identical) The British Standard is – 95% of all measurements should be with 2SD of the mean difference   Then they should […]

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Virtual Trials. Must Be Good! $31m Funding For Expansion

Science 37 (with Sanofi providing strategic guidance!) raised a mere $31m to enable ‘clinical trial access for anyone, anywhere, anytime’ using their technology platform for virtual trials (NORA). Apparently bringing trial needs from investigator sites into patients homes. Decentralising setup, decreasing costs and increasing recruitment. Must be good? May never see an actual patient then? […]

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WHY DO YOU NEED ‘NATURAL LANGUAGE PROCESSING’ IN AN IRS?

  See  4G Clinical – They raised $5m to build NLP into their randomisation and trial supply management system (RTSM). Must be good – It made the news!!! >>> http://www.4gclinical.com/blog/4g-clinical-launches-rtsm-software    

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SmartWatch Use Of Accelerometer Sensor

Take a look at this amazing functionality from a normal smartwatch for a view of the future of tech 🙂   >>

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