09- POTENTIAL NEW TREATMENTS

Toxic Nerve Agents

All very topical given the last weekends activities in our little own hometown – Salisbury! Looks like these nerve toxins like Sarin and Vx are just pumped up versions of the Acetylcholine esterase inhibitors we use for Alzheimers! They like our old friend galantamine (we did all the early development work) just block the breakdown […]

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Immunological Basis To AD Treatment

Think we’ve heard this story a thousand time before and every Global pharma Phase III trial has failed with it! I thought they’d realised that targeting AB protein had a basic flaw – that is that some people have amyloid plaques but no AD! >>>Immunological Target<<<

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Alzheimers ‘Brain’ Prize

Goedert, De Strooper, Hardy and Haas – leaders in neurological research! I like Hardy’s comment about current treatments being prescribed too late after the onset of the disease It’s unlikely we’ll find a revolutionary treatment but hopefully we’ll make small steps in to slowing the disease in the next few years <<BRAIN>>

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Treatment Of Pain

Very interesting approach and very topical given major cancers with Opioid addiction and abuse (eg: suboxone) Rather than targeting brain sensation target molecular pathway sending message to brain through protein Opens possibility to whole range of treatments for different pain related illnesses >>>PAIN<<<

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Hemostasis – Nanoparticles Of Thrombin

Interesting idea and maybe better than some of the devices we’ve been working on 🙂 Not sure I trust Russians though at the moment <<Hemostasis>>    

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Brain Plasticity – Valproate

Interestingly researchers think the brain potential rewiring may just be turned off with age Valproate an epilepsy drug might help in stroke >>>STROKE<<<

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WE’RE BACK!!

By popular demand we will restart the blog commenting on interesting daily news items We’ll start with a bit of a catch up – posting interesting items from the last few months 🙂

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Personalised Adverse Events!

Another use for stem cell technology I did talk to Aidan Courtney at Censobio.com who expects to do a similar thing – predicting response to AD treatment with stem cell testing>>> http://newatlas.com/stem-cells-personalized-testing-cancer-drug/48178/?utm_source=Gizmag+Subscribers&utm_campaign=08c7982cf2-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-08c7982cf2-91677545

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Yet Another Failure In AD!!!

Lundbeck’s 5-HT6 antafonist (idalopirdine ) has failed in 3 attempts >>> http://www.fiercebiotech.com/biotech/lundbeck-calls-time-alzheimer-s-drug-after-more-failure?utm_medium=nl&utm_source=internal&mrkid=938224&mkt_tok=eyJpIjoiTkdNNU1UZGxNR05pTjJJeiIsInQiOiJxWnhDQTcySXZCQm1MeTE4THZXWEVnTlZGa1JNMVRVOVNmVFFCUHZTWjJrZkRBdjJPY2Zxd0l0aVdOOEZaMVwvWFdSNUI0dlNaaFArWWd2eVNNUGJndllOVDZKdjZ2ZUREdmQyWDIzcTdmOFRtMHpuYmp1QUpSYUxObU9mSmo2NXQifQ%3D%3D

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Does This Mean There’ll Be Competition For LSD In Dementia In Future?

The benefits of microdosing LSD, although cognition wasn’t specifically mentioned>>>> http://newatlas.com/lsd-long-trip/47551/?utm_source=Gizmag+Subscribers&utm_campaign=2a58092796-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-2a58092796-91677545

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