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Male Contraceptive: dimethandrolone

Do you really want to be messing with vital hormones!!! Testosterone lowering is not a good idea in my book They have no idea of the long term effects or what else they potentially impair like growth and cell repair   <<<TESTOSTERONE>>>

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UK Increasing Mortality Rate

Interestingly they reckon not due to ageing, flu or cold weather but might be up turn in cancelled operations Would be an interesting modelling project 🙂   <<<MORTALITY>>>

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Toxic Nerve Agents

All very topical given the last weekends activities in our little own hometown – Salisbury! Looks like these nerve toxins like Sarin and Vx are just pumped up versions of the Acetylcholine esterase inhibitors we use for Alzheimers! They like our old friend galantamine (we did all the early development work) just block the breakdown […]

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The ‘Amazon’ Approach To Clinical Trial Recruitment

Nicely put – rather have the patient ‘shop’ at the clinic take the ‘shop’ on line to the patient 🙂 Ok if the condition your treating allows for home assessment and you can validate ‘real life’ data But always useful for follow ups <<<AMAZON>>>

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Immunological Basis To AD Treatment

Think we’ve heard this story a thousand time before and every Global pharma Phase III trial has failed with it! I thought they’d realised that targeting AB protein had a basic flaw – that is that some people have amyloid plaques but no AD! >>>Immunological Target<<<

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Alzheimers ‘Brain’ Prize

Goedert, De Strooper, Hardy and Haas – leaders in neurological research! I like Hardy’s comment about current treatments being prescribed too late after the onset of the disease It’s unlikely we’ll find a revolutionary treatment but hopefully we’ll make small steps in to slowing the disease in the next few years <<BRAIN>>

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Treatment Of Pain

Very interesting approach and very topical given major cancers with Opioid addiction and abuse (eg: suboxone) Rather than targeting brain sensation target molecular pathway sending message to brain through protein Opens possibility to whole range of treatments for different pain related illnesses >>>PAIN<<<

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Shire New Drug Application

Not everything they do is aimed at rare disease <<<Constipation>>

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Novel Way To Boost Patient Recruitment

I’ve been waiting for something like this for sometime Gives the CRO/Phar,ma more control over patient recruitment Can’t be bad! >>> <<Recruitment>>>

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Hemostasis – Nanoparticles Of Thrombin

Interesting idea and maybe better than some of the devices we’ve been working on 🙂 Not sure I trust Russians though at the moment <<Hemostasis>>    

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