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NICE Ruling Combined Therapy For AD

I thought combined therapy was already approved Worth trying anything once the AD symptoms appear! Even though I’ve never been convinced about memantine <<<MEMANTINE>>>

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Roadmap For Drug Development

Useful read >>> <<<ROADMAP>>>

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A Registry For Patients, By Patients

An interesting idea <<<REGISTRY>>>

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High Placebo Response In Depression (MDO)

This article refers to the high placebo response rate (50%) in MDO specifically but equally appplies to all therapeutic areas >>> >>>GET RECRUITMENT RIGHT -True MDO patients -True assessment by clinicians to select right subjects (keen to influence score on in/ex) -Personnel lack of understanding of AIM = to test null hypothesis /estimate treatment effect […]

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Caffeine

This trial in 100 cycling subjects confirmed what I already suspected I am a 1 in 10 when it comes to caffeine response – I get really drowsy not super stimulated! 50% stimulated / 40% no effect / 10% lethargic It’s all down to cytochrome P450s again   <<<CAFFEINE>>>

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BlockChain And EHR!

This is going to be huge These companies have access to vast EHR databases and this will speed access to doctors, to patients and to records! <<<BLOCKCHAIN>>>

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Blockchains For Clinical Research?

What a brilliant idea! Blocks of information linked by unique identifiers to the input (node) and output (next block) – So any change to it invalidates the block No central authority (‘middle man’) and no corruption Model: Nodes/Transactions/Data/Logic First off – individual patient medical health records – self retained and encrypted! Second – Regulatory bodies […]

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Psychohistory – Asimov World Of Big Data

Using historical data to predict future population actions – epidemics to genocide! Not something that’s too far off reality   <<<BIG DATA>>>

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Cognitive Enhancement

I’m not so sure more or everything is a good thing – Typical ‘greedy’ human state though! Brain implants to improve learning, memory, communication (brain to brain) or heighten sensation!   <<<COGNITION>>>

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Investigator Payments

A large proportion (84%) of NHS hospitals apparently still don’t declare finances received from drug companies Isn’t this a violation of the ABPI code of practice? I don’t see what the problem is BOTH Investigators (and Patients!) should be paid for work performed in clinical development BUT it all should be in the open and […]

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