02- CLINICAL DEVELOPMENT

Roadmap For Drug Development

Useful read >>> <<<ROADMAP>>>

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A Registry For Patients, By Patients

An interesting idea <<<REGISTRY>>>

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High Placebo Response In Depression (MDO)

This article refers to the high placebo response rate (50%) in MDO specifically but equally appplies to all therapeutic areas >>> >>>GET RECRUITMENT RIGHT -True MDO patients -True assessment by clinicians to select right subjects (keen to influence score on in/ex) -Personnel lack of understanding of AIM = to test null hypothesis /estimate treatment effect […]

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Caffeine

This trial in 100 cycling subjects confirmed what I already suspected I am a 1 in 10 when it comes to caffeine response – I get really drowsy not super stimulated! 50% stimulated / 40% no effect / 10% lethargic It’s all down to cytochrome P450s again   <<<CAFFEINE>>>

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BlockChain And EHR!

This is going to be huge These companies have access to vast EHR databases and this will speed access to doctors, to patients and to records! <<<BLOCKCHAIN>>>

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Blockchains For Clinical Research?

What a brilliant idea! Blocks of information linked by unique identifiers to the input (node) and output (next block) – So any change to it invalidates the block No central authority (‘middle man’) and no corruption Model: Nodes/Transactions/Data/Logic First off – individual patient medical health records – self retained and encrypted! Second – Regulatory bodies […]

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Alzheimers Disease And Amyloid Plaques

Anitbodies to amyloid plaques – now haven’t we heard that before somewhere? Hasn’t worked yet – because the neuronal damage is already done and empyting the ‘dustbin’ won’t help!   <<<PLAQUES>>>

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Israels Big Database

Electronic health records made publicly available for research Netanyahu obviously reckons they can may ‘big money’ from it!   <<BIG DATA>>>

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AI: All The Hype!!!

AI and Big Data words are ‘all the rage’ Companies are making a fortune and raising millions in VC funding claiming to do something very new and fancy! All they’re doing is repurposing compounds based on ‘mining’ existing data >> Atomwise/Benevolant/Twoxar/Numedii To do it they’re just using graphical analytics to look for patterns and trends or […]

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CANTAB Reckon ‘Most’ Patients Prefer Computer Based Testing!!!

In an elderly population 54% preferred CBT – since when was that ‘MOST’ And surprise surprise CANTAB provide a computer based battery !!!! What I did like though – was that most subjects preferred testing at home! <<<TESTING>>

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